Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress

► The mTORC2 kinase component Protor-2 is found to interact with the mRNA destabilizing factor tristetraprolin. ► Modulation of Protor-2 levels specifically alters the stability of mRNAs known to be degraded by tristetraprolin. ► Inhibition of Protor-2 expression blocks the association of tristetraprolin with stress granules or processing bodies during stress. ► We conclude that Protor-2 regulates tristetraprolin mediated mRNA turnover and may link mTORC2 signaling to regulated mRNA stability.