کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10817240 | 1058749 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of analytical performance and comparison of clinical results of the new generation method AccuTnIÂ +Â 3 for the measurement of cardiac troponin I using both patients and quality control plasma samples
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Evaluation of analytical performance and comparison of clinical results of the new generation method AccuTnIÂ +Â 3 for the measurement of cardiac troponin I using both patients and quality control plasma samples Evaluation of analytical performance and comparison of clinical results of the new generation method AccuTnIÂ +Â 3 for the measurement of cardiac troponin I using both patients and quality control plasma samples](/preview/png/10817240.png)
چکیده انگلیسی
The study aims are to evaluate the analytical performance and the clinical results of the chemiluminescent Access AccuTnIÂ +Â 3 immunoassay for the determination of cardiac troponin I (cTnI) with DxI 800 and Access2 platforms and to compare the clinical results obtained with this method with those of three cTnI immunoassays, recently introduced in the European market. The limits of blank (LoB), detection (LoD), and quantitation (LoQ) at 20% CV and 10% CV were 4.5Â ng/L and 10.9Â ng/L, 17.1 and 30.4Â ng/L, respectively. The results of STAT Architect high Sensitive TnI (Abbott Diagnostics), ADVIA Centaur Troponin I Ultra (Siemens Healthcare Diagnostics), ST AIA-Pack cTnI third generation (Tosoh Bioscience), and Access AccuTnIÂ +Â 3 (Beckman Coulter Diagnostics) showed very close correlations (R ranging from 0.901 to 0.994) in 122 samples of patients admitted to the emergency department. However, on average there was a difference up to 2.4-fold between the method measuring the highest (ADVIA method) and lowest cTnI values (AccuTnIÂ +Â 3 method). The consensus mean values between methods ranged from 6.2% to 29.6% in 18 quality control samples distributed in an external quality control study (cTnI concentrations ranging from 29.3Â ng/L to 1557.5Â ng/L). In conclusion, the results of our analytical evaluation concerning the AccuTnIÂ +Â 3 method, using the DxI platform, are well in agreement with those suggested by the manufacturer as well as those reported by some recent studies using the Access2 platform. Our results confirm that the AccuTnIÂ +Â 3 method for the Access2 and DxI 800 platforms is a clinically usable method for cTnI measurement.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 451, Part B, 7 December 2015, Pages 129-134
Journal: Clinica Chimica Acta - Volume 451, Part B, 7 December 2015, Pages 129-134
نویسندگان
Simona Storti, Silvia Masotti, Concetta Prontera, Maria Franzini, Paola Buzzi, Ivo Casagranda, Enrica Ciofini, Gian Carlo Zucchelli, Rudina Ndreu, Claudio Passino, Aldo Clerico,