Monitoring of tacrolimus concentrations in peripheral blood mononuclear cells: Application to cardiac transplant recipients

► Determination of tacrolimus in peripheral blood mononuclear cells is proposed. ► First application of tacrolimus determination in PBMC in cardiac recipients. ► No correlation was found between TAC concentrations in PBMC and in whole blood. ► Large inter-individual variability of TAC concentrations in PBMC was highlighted. ► Monitoring TAC in PBMC could be more relevant to assess efficacy than in blood.