The galactosaminoglycan-containing decorin and its impact on diseases

► Mutation in the decorin gene causes opacity. ► Gene involved in the synthesis of CS/DS of decorin leads to defects in dermal collagen fibrils. ► Genes involved in the sulfation of CS/DS also lead to altered dermal collagen fibrils. ► Lack of decorin and changes in CS/DS structures might lead to an altered cell signaling.