High-pressure macromolecular crystallography and NMR: status, achievements and prospects

► Pressure-induced structural changes open new prospects to explore the conformational space of biomacromolecules. ► High-pressure macromolecular crystallography (HPMX) and high-pressure NMR on solutions of biomacromolecules (HPNMR) are now mature methods. ► These methods are complementary.