RRM-RNA recognition: NMR or crystallography…and new findings

► Versatility of RNA binding by RRMs using loops, α-helix 1 or domain extremities. ► Methods for detection of water molecules and their importance for RNA recognition. ► Advantage of combining NMR and crystallography for multiple RRM-containing proteins. ► Detection of conformational ensembles present in solution. ► NMR or crystallography: Which method should be used for RRM-RNA complexes?