کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10822630 | 1061672 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dynamics: the missing link between structure and function of the viral RNA-dependent RNA polymerase?
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Dynamics: the missing link between structure and function of the viral RNA-dependent RNA polymerase? Dynamics: the missing link between structure and function of the viral RNA-dependent RNA polymerase?](/preview/png/10822630.png)
چکیده انگلیسی
The structural basis for nucleotide incorporation fidelity remains an open question for all nucleic acid polymerases. Addressing this question for the viral RNA-dependent RNA polymerase (RdRp) is of particular, practical significance because it is a determinant of sensitivity to antiviral nucleosides and may be a determinant of viral virulence. All polymerases are thought to employ the same catalytic mechanism, but the rate of nucleotide incorporation can vary substantially. Here we review some of the recent work with the RdRp that leads us to suggest that structure provides only a partial understanding of RdRp function and dynamics may be the missing link.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Structural Biology - Volume 19, Issue 6, December 2009, Pages 768-774
Journal: Current Opinion in Structural Biology - Volume 19, Issue 6, December 2009, Pages 768-774
نویسندگان
Craig E Cameron, Ibrahim M Moustafa, Jamie J Arnold,