کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10822676 | 1061693 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Determination of conformationally heterogeneous states of proteins
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Determination of conformationally heterogeneous states of proteins Determination of conformationally heterogeneous states of proteins](/preview/png/10822676.png)
چکیده انگلیسی
Although conformationally heterogeneous states of proteins are involved in a range of important biological processes, including protein folding and misfolding, and signal transduction, detailed knowledge of their structure and dynamics is still largely missing. Proteins in many of these states are constantly changing shape, such that they are better described as ensembles of conformations rather than in terms of well-defined structures, as is normally the case for native states. Methods in which molecular simulations are combined with experimental measurements are emerging as a powerful route to the accurate determination of the conformational properties of these states of proteins.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Structural Biology - Volume 17, Issue 1, February 2007, Pages 15-20
Journal: Current Opinion in Structural Biology - Volume 17, Issue 1, February 2007, Pages 15-20
نویسندگان
Michele Vendruscolo,