کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10822681 | 1061693 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ultrafast and downhill protein folding
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Ultrafast folding proteins have served an important role in benchmarking molecular dynamics simulations and testing protein folding theories. These proteins are simple enough and fold fast enough that realistic simulations are possible, which facilitates the direct comparison of absolute folding rates and folding mechanisms with those observed experimentally. Such comparisons have achieved remarkable success, but have also revealed the shortcomings that remain in experiment, theory and simulation alike. Some ultrafast folding proteins may fold without encountering an activation barrier (downhill folding), allowing the exploration of the molecular timescale of folding and the roughness of the energy landscape. The biological significance of ultrafast folding remains uncertain, but its practical significance is crucial to progress in understanding how proteins fold.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Structural Biology - Volume 17, Issue 1, February 2007, Pages 38-47
Journal: Current Opinion in Structural Biology - Volume 17, Issue 1, February 2007, Pages 38-47
نویسندگان
R Brian Dyer,