کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10822766 | 1061705 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A decade of CASP: progress, bottlenecks and prognosis in protein structure prediction
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
For the past ten years, CASP (Critical Assessment of Structure Prediction) has monitored the state of the art in modeling protein structure from sequence. During this period, there has been substantial progress in both comparative modeling of structure (using information from an evolutionarily related structural template) and template-free modeling. The quality of comparative models depends on the closeness of the evolutionary relationship on which they are based. Template-free modeling, although still very approximate, now produces topologically near correct models for some small proteins. Current major challenges are refining comparative models so that they match experimental accuracy, obtaining accurate sequence alignments for models based on remote evolutionary relationships, and extending template-free modeling methods so that they produce more accurate models, handle parts of comparative models not available from a template and deal with larger structures.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Structural Biology - Volume 15, Issue 3, June 2005, Pages 285-289
Journal: Current Opinion in Structural Biology - Volume 15, Issue 3, June 2005, Pages 285-289
نویسندگان
John Moult,