Differential contribution of XPC, RAD23A, RAD23B and CENTRIN 2 to the UV-response in human cells

► We characterized the first steps of global-genome repair in human cells. ► We examined the UVC-response of cells silenced for XPC and RAD23Aand/orB genes. ► RAD23A and RAD23B display distinct roles in DNA repair. ► XPC is essential for the localization of CENTRIN 2 to nuclear damaged areas. ► The CENTRIN 2 trapping may indirectly perturb proliferation and contribute to NER.