کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1082532 950952 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Conclusion about the association between valve surgery and mortality in an infective endocarditis cohort changed after adjusting for survivor bias
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی سیاست های بهداشت و سلامت عمومی
پیش نمایش صفحه اول مقاله
Conclusion about the association between valve surgery and mortality in an infective endocarditis cohort changed after adjusting for survivor bias
چکیده انگلیسی

ObjectiveSurvivor bias commonly weakens observational studies, even those published in premier journals. It occurs because patients who live longer are more likely to receive treatment than those who die early. We sought to quantify the effect of survivor bias on the association between valve surgery and mortality in infective endocarditis (IE).Study Design and SettingThe study cohort included 546 IE patients. We compared the hazard ratios (HR) resulting from two propensity score analysis approaches that adjusted for survivor bias (time-dependent variable and matching on follow-up time) with those achieved using the same models but without that adjustment (time-fixed variable).ResultsIn the total cohort, the HR of surgery in the time-dependent model was 1.9 (95% confidence interval [CI] = 1.1–3.2; P = 0.03) vs. 0.9 (95% CI = 0.5–1.4; P = 0.53) in the time-fixed model. In the propensity score–matched subset, the HR of surgery was 1.3 (95% CI = 0.5–3.1; P = 0.56) and 0.8 (95% CI = 0.4–1.7; P = 0.57) in the subset with and without matching on follow-up time, respectively.ConclusionAdjusting for survivor bias changed the conclusion about the association between valve surgery and mortality in IE. Researchers should be aware of this bias when evaluating observational studies of treatment efficacy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Epidemiology - Volume 63, Issue 2, February 2010, Pages 130–135
نویسندگان
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