Methods of studying telomere damage induced by quadruplex-ligand complexes

► Experimental approaches to analyze telomere damage induced by G-quadruplex ligands. ► Telomere uncapping investigation by analyzing DNA damage markers at telomeres. ► Evaluation of telomeric protein localization. ► Cytogenetic analysis of telomere aberrations in metaphases preparations. ► Replication fork stall analysis at telomeres by combing BrdU incorporation and ChIP.