کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1082623 950958 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Individuals with diabetes preferred that future trials use patient-important outcomes and provide pragmatic inferences
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی سیاست های بهداشت و سلامت عمومی
پیش نمایش صفحه اول مقاله
Individuals with diabetes preferred that future trials use patient-important outcomes and provide pragmatic inferences
چکیده انگلیسی

ObjectiveWe sought to examine patients' preferences regarding the design of diabetes trials. Specifically, do patients prefer trials to focus on patient-important outcomes (vs. surrogate outcomes) and provide practical/pragmatic answers (vs. mechanistic/explanatory answers)?Study Design and SettingWe mailed a questionnaire to a stratified random sample of 4,796 patients with diabetes receiving care from 371 primary care clinicians in the US Midwest. Medical record review provided data on hemoglobin A1c (HbA1c). Descriptive statistics, logistic regression, and multiple regression techniques were used for analysis.ResultsWe received completed surveys from 2,036 patients (response rate of 42.5%). On average, respondents were 65 years old, had 11 years of diabetes, and had excellent glycemic control (HbA1c = 7%). Most patients (>75%) chose patient-important outcomes rather than HbA1c as their first choice for a trial primary outcome and preferred a practical trial design. Patients with poor glycemic control (HbA1c > 8.0%) were more likely to prefer HbA1c as a primary end point (odds ratio: 1.5; 95% confidence interval: 1.1, 2.1).ConclusionIndividuals with diabetes report a strong preference for practical trials measuring the effect of treatments on patient-important outcomes. To our knowledge, this is the first report of patients endorsing key elements of the comparative effectiveness agenda.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Epidemiology - Volume 64, Issue 7, July 2011, Pages 743–748
نویسندگان
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