Skin microdialysis coupled with Laser Speckle Contrast Imaging to assess microvascular reactivity

► Skin microdialysis coupled with LSCI is feasible and reproducible. ► It provides two-dimensional information. ► Subdermal placement is the best choice compared with intradermal placement using 21 G introducing needles. ► 29 mM SNP or 43 °C local heating can be used as maximal CVC.