High glucose impairs EDHF-mediated dilation of coronary arterioles via reduced cytochrome P450 activity

► HG impairs endothelium-dependent vasodilation in coronary arterioles. ► HG impairs EDHF-mediated arteriolar dilation via the elevation of superoxide. ► HG reduces endothelial cytochrome P450 (CYP) activity and EET production. ► HG reduces CYP activity by increasing superoxide production.