Effect of Mitofusin 2 on smooth muscle cells proliferation in hypoxic pulmonary hypertension

► Mfn2 expression was upregulated in hypoxia. ► Mfn2 mediated hypoxia-induced PASMCs proliferation. ► Mfn2 increased AKT activity in PASMCs. ► Mfn2 induced PASMCs proliferation via the PI3K/Akt pathway.