Role of convection and diffusion on DCE-MRI parameters in low leakiness KHT sarcomas

► Vascular permeability measurement is a combination of multiple transport phenomena. ► Important to account for transport phenomena in low vessel permeability tumors ► Porous media model showed better contrast agent kinetics than the compartment model. ► Scaling permeability may be needed to account for reduction due to convection. ► Fluid flow requires scaling of 2-compartment derived Ktrans for porous media model.