Y1R control of sciatic nerve blood flow in the Wistar Kyoto rat

► Y1R activation or blockade exerted minimal effect on baseline nerve blood flow. ► Ganglionic blockade induced late (after 30 min) dilatory effects on nerve blood flow. ► Y1R activation reversed the vasodilation induced by ganglionic blockade. ► Western blot analysis provides evidence for Y1R expression in the rat sciatic nerve.