Post-transcriptional regulation of placenta growth factor mRNA by hydrogen peroxide

► A single, low dose of H2O2 increases the half-life of PLGF mRNA in human CASMC. ► The H2O2 induced increase in PLGF mRNA levels depends, in part, on kinase signaling. ► Chronic exposure to H2O2 induces an even greater elevation of PLGF mRNA. ► Elevated PLGF mRNA due to chronic exposure does not result in increased PLGF protein.