Inhibition of endothelial/smooth muscle cell contact loss by the investigational angiopoietin-2 antibody MEDI3617

► Exogenous Ang-2 stimulation of spheroids results in endothelial cell loss. ► Ang-2 antibody, MEDI3617, inhibits Ang-2 dependent endothelial cell loss. ► PMA stimulates endothelial cell loss of spheres in dose dependent manner. ► MEDI3617 able to decrease PMA induced endothelial cell loss even at a small dose. ► MEDI3617 reduces renal cell induced blood vessels in an in vivo intradermal assay.