Effects of acute hypercapnia on the amplitude of cerebrovascular pulsation in humans registered with a non-invasive method

► Acute hypercapnia causes an increase in pial artery pulsation in humans. ► NIR-T/BSS allows for non-invasive monitoring of microvessel pulsation. ► NIR-T/BSS is consistent with TCD and SPECT. ► Further studies on patients with diseases affecting brain microvessels are warranted.