Distinct microhemodynamic efficacy of arteriogenesis and angiogenesis in critically ischemic skin flaps

► We demonstrate orchestration of vascular regeneration in a critically ischemic skin flap. ► Arteriogenesis and angiogenesis exhibit distinct microhemodynamic efficacy time wise. ► Arteriogenesis is correlated to eNOS expression and responds early in collateral arterioles. ► Angiogenesis is correlated to VEGF expression is secondary to arteriogenesis in our model.