Enhancement of long-term angiogenic efficacy of adipose stem cells by delivery of FGF2

► Human adipose-derived stem cell (hADSC) transplantation induces neovascularization. ► We delivered FGF2 to hADSC transplantation sites in ischemic limbs. ► FGF2 delivery enhanced long-term survival and paracrine factor secretion of hADSCs. ► The long-term stability of arterioles generated by hADSC transplantation increased. ► FGF2 delivery enhanced long-term angiogenic efficacy of transplanted hADSC.