Muscle endothelial-dependent microvascular dysfunction in adulthood due to early postnatal overnutrition

► Postnatal overnutrition is an important modulator of cardiovascular disturbances. ► Postnatal overnutrition induced microvascular dysfunction. ► Postnatal overnutrition increases total fat percentage and impairs the lipid profile. ► This experimental model of obesity influences microvascular reactivity later in life. ► Microvascular dysfunction precedes the obesity and dyslipidemia.