کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1082981 950978 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Retrospective cohort study highlighted outcome reporting bias in UK publicly funded trials
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی سیاست های بهداشت و سلامت عمومی
پیش نمایش صفحه اول مقاله
Retrospective cohort study highlighted outcome reporting bias in UK publicly funded trials
چکیده انگلیسی

ObjectiveTo assess outcome reporting bias and dissemination bias in trials funded by the National Health System (NHS) Health Technology Assessment (HTA) program.Study Design and SettingA retrospective cohort study of HTA monographs and corresponding journal publications including all clinical effectiveness randomized controlled trials published as HTA monographs between 1999 and 2005 by the NHS HTA program.ResultsThere was a higher median P-value (P = 0.33, interquartile range [IQR]: 0.02–0.54) among trials without a journal publication compared with those with a journal publication (P = 0.14, IQR: 0.007–0.43), although the difference was not statistically significant (Mann-Whitney U test, z = −0.70; P = 0.48). A higher proportion of statistically significant findings were reported in journal articles when compared with the outcomes reported in the HTA monographs. Trials published in general medical journals tended to have smaller P-values (median: 0.05, IQR: 0.001–0.22) than those published in more specialist journals (median: 0.33 IQR: 0.008–0.58), although this result was not significant (Mann-Whitney U test, z = −1.63; P = 0.10).ConclusionsAmong journal-published trials, there were a greater proportion of statistically significant findings included in the journal reports compared with those in the HTA monographs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Epidemiology - Volume 64, Issue 12, December 2011, Pages 1317–1324
نویسندگان
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