کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10833 703 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Poly(vinyl alcohol)–acrylamide hydrogels as load-bearing cartilage substitute
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Poly(vinyl alcohol)–acrylamide hydrogels as load-bearing cartilage substitute
چکیده انگلیسی

Poly(vinyl alcohol) (PVA) has been advanced as a biomaterial for the fabrication of medical devices to be used as synthetic articular cartilage because of its viscoelastic nature, high water content, and biocompatibility. Key material requirements for such devices are high creep resistance to prevent mechanical instability in the joint and high water content to maintain a lubricious surface to minimize wear and damage of the cartilage counterface during articulation. The creep resistance of PVA hydrogels can be increased by high temperature annealing; however this process also collapses the pores, reducing the water content and consequently reducing the lubricity of the hydrogel surface [Bodugoz-Senturk H, Choi J, Oral E, Kung JH, Macias CE, Braithwaite G, et al. The effect of polyethylene glycol on the stability of pores in polyvinyl alcohol hydrogels during annealing. Biomaterials 2008;29(2):141–9.]. We hypothesized that polymerizing acrylamide (AAm) in the pores of the PVA hydrogel would minimize the loss of lubricity during annealing by preventing the collapse of the pores and loss of water content. Increasing AAm content increased porosity and equilibrium water content and decreased the coefficient of friction, tear strength, crystallinity, and creep resistance in annealed PVA hydrogels.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 30, Issue 4, February 2009, Pages 589–596
نویسندگان
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