Citrulline and arginine utility in treating nitric oxide deficiency in mitochondrial disorders

► Nitric oxide (NO) deficiency can contribute to mitochondrial diseases complications. ► NO deficiency in mitochondrial disorders can result from multiple factors. ► Arginine and citrulline supplementation can result in increased NO production. ► Arginine and citrulline can have therapeutic effects in mitochondrial diseases. ► Controlled clinical studies of the effects of arginine or citrulline are needed.