A shortcut to the lysosome: The mannose-6-phosphate-independent pathway

► Description of the mannose-6-phoshate(M6P)-independent pathway for lysosomal targeting. ► Current knowledge synthesis on the alternative receptors involved in it: sortilin and LIMP2. ► Evaluation of the impact of known impairments in this transport pathway. ► Special attention paid to action myoclonus-renal failure syndrome (autosomal recessive disorder). ► Also referenced: sortilin and disease - the cardiovascular risk locus.