Tnfα, Cox2 and AdipoQ adipokine gene expression levels are modulated in murine adipose tissues by both nicotine and nACh receptors containing the β2 subunit

► Differential expression of nAChR subunit genes in mouse WAT and BAT was detected. ► Nicotine administration significantly affected the expression of adipokine genes. ► Interaction between β2 subunit and nicotine affected adipokine gene expression. ► Nicotine treatment of si-β2nAChR adipocytes significantly elevated Cox2 expression.