Methionine-induced hyperhomocysteinemia and bleomycin hydrolase deficiency alter the expression of mouse kidney proteins involved in renal disease

Our findings indicate that Blmh interacts with diverse cellular processes - lipoprotein, amino acid and protein, carbohydrate, and energy metabolisms, detoxification, antioxidant defenses - that are essential for normal kidney homeostasis and that deregulation of these processes can account for the involvement of HHcy in kidney disease.