Population variability in CD38 activity: Correlation with age and significant effect of TNF-α -308G > A and CD38 184C > G SNPs

► Here we assessed the distribution of CD38 NADase activity in a healthy population. ► The mean value of CD38 NADase activity was 0.051 ± 0.023 mU/mg (0.010-0.099 mU/mg). ► TNF-α rs1800629 resulted the main predictor, followed by Age and CD38 184 C > G rs6449182. ► The use of rs1800629 and rs6449182 as predictive markers of CD38 activity, point toward a pharmacogenomic use.