کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1083417 951000 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Dutch diagnostic model for laboratory animal allergen sensitization was generalizable in Canadian apprentices
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی سیاست های بهداشت و سلامت عمومی
پیش نمایش صفحه اول مقاله
The Dutch diagnostic model for laboratory animal allergen sensitization was generalizable in Canadian apprentices
چکیده انگلیسی

ObjectiveTo assess the transportability of an existing diagnostic questionnaire model for the sensitization to laboratory animal (LA) allergens.Study Design and SettingThe model was externally validated in 414 Canadian animal health apprentices. Several approaches were used: (1) no adjustment; (2) recalibration of the intercept of the model; (3) re-estimation of the intercept and the regression coefficients of predictors; and (4) model revision, by excluding the existing predictor(s) and/or including new predictor(s). The bootstrapping procedure was done following the third and fourth methods. The calibration was assessed graphically and with the Hosmer–Lemeshow (HL) test. Discriminative properties were determined by the area under the receiver operating characteristic curve (ROC area).ResultsWhen applied without adjustment, the model's discriminative ability was adequate (ROC area was 0.74 vs. the original ROC area of 0.76); the calibration was poor (HL test P < 0.001). The other methods yielded models with good calibration (P > 0.10) and reasonable discrimination (ROC area ranged between 0.73 and 0.75). The refitted and revised model showed a good internal validity (correction factor from the bootstrapping procedure was more than 0.90).ConclusionOnce updated, the diagnostic model is valid and can be applied with reasonable performance in an animal health apprentice setting.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Epidemiology - Volume 62, Issue 5, May 2009, Pages 542–549
نویسندگان
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