Noradrenaline activates the NO/cGMP/ATP-sensitive K+ channels pathway to induce peripheral antinociception in rats

► It was investigated the involvement of NO/cGMP/KATP in NA-induced antinociception. ► The rat paw PGE2-induced hyperalgesia and pressure test was used. ► l-NOarg and glibenclamide antagonized the antinociception effect induced by NA. ► ODQ antagonized and zaprinast potentiated the NA-induced antinociception. ► NA induces peripheral antinociceptive effect by activation of NO/cGMP/KATP pathway.