Doxycycline ameliorates 2K-1C hypertension-induced vascular dysfunction in rats by attenuating oxidative stress and improving nitric oxide bioavailability

► Doxycycline is known to inhibit matrix metalloproteinase (MMP). ► This effect is associated with improved vascular function in hypertension. ► We showed that doxycycline exerts antioxidant effects and improves NO availability. ► These effects may contribute to its antihypertensive effects.