Dermal application of nitric oxide releasing acidified nitrite-containing liniments significantly reduces blood pressure in humans

► Dermal application of NO led to a very rapid translocation of NO into the underlying tissue. ► Dermal application of NO led to systemic increase in concentration of the NO derivates nitrite and nitroso compounds. ► Dermal application of NO led to increased systemic vasodilatation and blood flow as well as reduced blood pressure.