Elevated concentration of asymmetric dimethylarginine (ADMA) in individuals with metabolic syndrome

We studied 85 adult individuals from Talca, Chile, separated in two groups, 48 individuals with MS (according to modified ATP III criteria), and 37 individuals without MS as controls. ADMA levels were significantly increased in the MS group (mean ± standard deviation 0.71 ± 0.38 vs. 0.48 ± 0.28 μmol/L, p = 0.0009). Furthermore, the levels of ADMA were modestly but significantly correlated with waist circumference (p = 0.01) but not with the other components of MS (blood pressure, glycemia, triglycerides and high density lipoprotein cholesterol HDL-c). These results suggest a possible link between increased ADMA levels and the MS.