Nitrite and nitric oxide metabolism in peripheral artery disease

► Nitrite anion is important in the functional and pathophysiological responses in PAD. ► We discuss NO bioavailability in PAD and plasma nitrite as a source of NO in hypoxia. ► We discuss endogenous and exogenous sources of plasma nitrite. ► We review the effects on vascular structure, function and physical performance. ► We highlight basic findings translated to animal and human models.