Atypical PKCζ transduces electrophilic fatty acid signaling in pulmonary epithelial cells

► Within pulmonary epithelial cells the nitrated fatty acid, ► nitrolinoleate, inhibits calcium influx. ► Inhibition of calcium influx does not occur through an NO-cGMP pathway. ► Treatment of pulmonary epithelial cells results in the activation of the MAP Kinase Erk. ► Nitrolinoleate effects in epithelial cells are PKC-dependent. ► Nitrolinoleate binds to PKCzeta, potentially via Michael addition, resulting in translocation to the membrane and activation.