Neurohypophyseal hormones protect against pentylenetetrazole-induced seizures in zebrafish: Role of oxytocin-like and V1a-like receptor

► We studied the neurohypophyseal hormones on seizures in zebrafish. ► We evaluated the epileptic behavior induced by pentylenetetrazole. ► Oxytocin (OT), vasopressin, isotocin and vasotocin reduced epileptic behavior. ► OT and vasopressin V1a receptor antagonists selectively antagonized the protection. ► These hormones are anticonvulsant agents through a receptor-mediated mechanism.