کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1083672 951015 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Estimated progression rates in three United Kingdom hepatitis C cohorts differed according to method of recruitment
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی سیاست های بهداشت و سلامت عمومی
پیش نمایش صفحه اول مقاله
Estimated progression rates in three United Kingdom hepatitis C cohorts differed according to method of recruitment
چکیده انگلیسی

ObjectivesTo estimate hepatitis C virus (HCV) progression rates between disease stages prior to cirrhosis, using data from liver biopsies in three observational cohorts. To demonstrate how the method of cohort recruitment can influence the estimation of HCV-progression rates.Study Design and SettingData came from three United Kingdom observational cohorts, assembled from different referral sources. In total, 987 HCV-infected patients with an estimated (or known) date of infection and at least one histologically scored liver biopsy were eligible for inclusion in the analysis. Liver biopsy scores were used to determine the stage of HCV-related liver disease. A three-state continuous time Markov model was used to estimate covariate-specific average probabilities of progression of disease.ResultsAfter adjusting for confounders, considerably different rates of disease progression were estimated in the three cohorts. For a group of patients with the same demographics, the estimated 20-year probability of progression to cirrhosis was 12% (95% confidence interval CI = 6–22) in a hospital-based cohort, 6% (95% CI = 3–13) in a posttransfusion cohort, and 23% (95% CI = 14–37) in a cohort recruited from a tertiary referral center.ConclusionResearchers using estimates of disease progression should be aware that the method of cohort recruitment has considerable influence on the progression rates that are derived.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Epidemiology - Volume 59, Issue 2, February 2006, Pages 144–152
نویسندگان
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