Dose-dependent changes in the locomotor responses to methamphetamine in BALB/c mice: Low doses induce hypolocomotion

► Lower doses of methamphetamine (meth) cause hypolocomotion in BALB/c mice. ► Moderate doses of meth induce hyperlocomotion. ► Higher doses of meth induce hyperlocomotion and stereotypy. ► Prior exposure to meth attenuates/decreases hypolocomotion. ► Prior exposure to meth leads to tolerance.