Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol

► Novel pharmacogenetic findings for naltrexone are demonstrated. ► Tag SNPs in kappa and delta opioid receptor genes are examined. ► OPRK1 SNP predicts sedative response to alcohol while on naltrexone. ► OPRD1 SNP predicts stimulation and craving responses to alcohol while on naltrexone.