Involvement of nitric oxide in pioglitazone memory improvement in morphine-induced memory impaired mice

► Pioglitazone improves the acquisition of memory impairment induced by morphine. ► L-NAME reversed the effects of pioglitazone on memory impaired by morphine. ► Aminoguanidine nullifies the memory enhancing effect of pioglitazone only in Y-maze. ► Nitric oxide pathway is involved in pioglitazone induced memory performance.