The role of the NMDA receptors and l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of duloxetine in the forced swimming test

► This study confirms the antidepressant-like effect of duloxetine in the FST. ► The mechanisms underlying antidepressant action of duloxetine was investigated. ► NMDA receptors and NO/cGMP synthesis inhibition is implicated in duloxetine effect. ► NMDA receptors and L-arginine-NO-cGMP pathway are targets for antidepressant action.