In vitro antioxidant activity and in vivo antidepressant-like effect of α-(phenylselanyl) acetophenone in mice

►α-(Phenylselanyl) acetophenone (PSAP) possesses in vitro antioxidant property. ►PSAP caused antidepressant-like effect in mice. ►Our result suggests the possible involvement of serotonergic system in this effect. ►PSAP did not cause oxidative tissue stress following treatment in mice.