Neuronal nicotinic receptor ligands modulate chronic nicotine-induced ethanol consumption in C57BL/6J mice

► Chronic nicotine treatment increased free-choice ethanol intake in mice. ► Cytisine pretreatment attenuated nicotine-induced ethanol intake and preference. ► Lobeline pretreatment reduced nicotine-induced ethanol consumption and preference. ► DHβE pretreatment did not suppress nicotine-induced ethanol intake or preference. ► Nicotinic receptors are critical in regulating nicotine-induced ethanol intake.