Experimental hypertension induced vascular dementia: Pharmacological, biochemical and behavioral recuperation by angiotensin receptor blocker and acetylcholinesterase inhibitor

► DOCA-salt hypertension induced endothelial dysfunction & vascular dementia (VaD). ► Hypertension increased MABP, oxidative stress, AChE activity and decrease NO. ► ARB and AChEI attenuated DOCA hypertension induced endothelial dysfunction and VaD. ► ARB and AChEI attenuated hypertension impaired learning, memory and biochemistry. ► ARB and AChEI showed pharmacological recuperation of DOCA hypertension induced VaD.