The antinociceptive activity of harmicine on chemical-induced neurogenic and inflammatory pain models in mice

► We examined the potential use of harmicine for pain relief. ► We tested using chemical assays of pain ► Harmicine demonstrated effectiveness against neurogenic pain stimuli. ► The compound seems to act peripherally via vanilloid and glutamatergic systems. ► Harmicine seems not to act via opioid system in the writhing test.