Role of ATP-sensitive K+ channels in the antinociception induced by non-steroidal anti-inflammatory drugs in streptozotocin-diabetic and non-diabetic rats

► Diclofenac, metamizol and indomethacin induced antinociception in STZ-diabetic rat. ► Lumiracoxib and meloxicam produced antinociception in the STZ-diabetic rats. ► Sulfonylureas block the diclofenac-induced antinociception in STZ-diabetic rats. ► Sulfonylureas do not block the antinociception of other NSAIDs in STZ-diabetic rat. ► The results with STZ-diabetic rats were reproduced in non-diabetic rats.